The Etiological and Prognostic Value of Factor VIII in Patients Diagnosed with Myocardial Infarction: A Prospective Controlled Randomized Study

Abstract

Aim: The purpose of this study was to evaluate the association between factor VIII (FVIII) and myocardial infarction. A comparative study was performed on patients diagnosed with acute myocardial infarction with/ non-ST-elevation myocardial infarction (STEMI/NSTEMI) and patients presenting with non-cardiac chest pain and no evidence of myocardial injury on electrocardiogram and troponin testing. Materials and Methods: We evaluated 55 patients with acute STEMI or NSTEMI. The control group consisted of individuals between the ages of 18 and 80 who presented to the emergency department with chest pain and had no electrocardiogram and troponin changes after 0, 1, and 3 hours of follow-up. Samples for FVIII levels were collected from patients and control group at minute 0 on admission. Results: The mean FVIII levels in the patient and control groups exhibited a notable disparity, yet this difference was not statistically significant. In the patient group, FVIII levels were compared between the STEMI and NSTEMI subgroups, and no significant discrepancy was identified (p=0.226). Furthermore, FVIII levels did not demonstrate a statistically significant divergence in patients with a prior diagnosis of coronary artery disease (p=0.79). In our acute coronary syndrome cohort, women exhibited significantly elevated FVIII levels compared to men. Conclusion: This study revealed no correlation between FVIII levels and acute myocardial infarction. The findings indicated that there is no significant difference between STEMI and NSTEMI for FVIII levels in subgroup analysis and no significant risk for recurrent coronary events.

Keywords

• acute coronary syndromes
• factor viii
• non-st elevated myocardial infarction