Longitudinal Observation of Asymmetric Iron Deposition in an Intracerebral Hemorrhage Model Using Quantitative Susceptibility Mapping

Keiho Tsuji; Ryutarou Onishi; Reika Sawaya; Narumi Arihara; Junpei Ueda; Shigeyoshi Saito

doi:10.3390/sym14020350

Symmetry (Feb 2022)

Longitudinal Observation of Asymmetric Iron Deposition in an Intracerebral Hemorrhage Model Using Quantitative Susceptibility Mapping

Keiho Tsuji,
Ryutarou Onishi,
Reika Sawaya,
Narumi Arihara,
Junpei Ueda,
Shigeyoshi Saito

Affiliations

Keiho Tsuji: Area of Medical Imaging Technology and Science, Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Ryutarou Onishi: Area of Medical Imaging Technology and Science, Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Reika Sawaya: Area of Medical Imaging Technology and Science, Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Narumi Arihara: Area of Medical Imaging Technology and Science, Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Junpei Ueda: Area of Medical Imaging Technology and Science, Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Shigeyoshi Saito: Area of Medical Imaging Technology and Science, Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan

DOI: https://doi.org/10.3390/sym14020350
Journal volume & issue: Vol. 14, no. 2
p. 350

Abstract

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Quantitative susceptibility mapping (QSM) is used to obtain quantitative magnetic susceptibility maps of materials from magnitude and phase images acquired by three-dimensional gradient-echo using inverse problem-solving. Few preclinical studies have evaluated the intracerebral hemorrhage (ICH) model and asymmetric iron deposition. We created a rat model of ICH and compared QSM and conventional magnetic resonance imaging (MRI) during the longitudinal evaluation of ICH. Collagenase was injected in the right striatum of 12-week-old Wistar rats. QSM and conventional MRI were performed on days 0, 1, 7, and 28 after surgery using 7-Tesla MRI. Susceptibility, normalized signal value, and area of the hemorrhage site were statistically compared during image analysis. Susceptibility decreased monotonically up to day 7 but increased on day 28. Other imaging methods showed a significant increase in signal from day 0 to day 1 but a decreasing trend after day 1. During the area evaluation, conventional MRI methods showed an increase from day 0 to day 1; however, decreases were observed thereafter. QSM showed a significant increase from day 0 to day 1. The temporal evaluation of ICH by QSM suggested the possibility of detecting of asymmetric iron deposition for normal brain site.

Published in Symmetry

ISSN: 2073-8994 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Mathematics
Website: http://www.mdpi.com/journal/symmetry/

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