Homeostatic responses to amino acid insufficiency

Abstract

This article provides a brief overview describing how two key signaling pathways, namely the integrated stress response and the mammalian target of rapamycin complex 1, work together to facilitate cellular adaptation to dietary amino acid insufficiency. A deeper understanding of these mechanisms is leading to identification of novel targets which aid in disease treatments, improve stress recovery and increase health span through slowed aging and enhanced metabolic fitness. Keywords: mTOR, GCN2, Integrated stress response, Asparaginase, Eukaryotic initiation factor 2, Activating transcription factor 4