Healing of diabetic ulcers in conditions of biological stimulation of reparation

Abstract

Purpose of study. The repertory effect evaluation of autologous platelet-rich plasma in the treatment of patients with diabetic foot in stage 2. Materials and methods. The study included 32 patients with diagnosisof diabetic foot in stage 2. At the time of inclusion in the study, all patients had a defect of the skin and subcutaneous fat on the foot, measuring 3–6 cm2, which was not corrected by traditional methods for 3–4 months. The comparison group consisted of 18 patients (56,25%) who received standard therapy. The study group consisted of 14 patients (43,75%), to whom standard therapy was supplemented by local serial administration of autologous platelet-rich plasma. To assess the effectiveness of the therapy, the area of the ulcerative defect was measured before manipulation, as well as at 1 week intervals until the ulcer was completely healed. Results. Our experience with autologous platelet-rich plasma in the treatment of patients with diabetic foot in stage 2 demonstrated the effectiveness of this technique. A progressive, significant (p < 0,01) decrease in the area of the ulcerative defect starting from the 14th day was noted. When using platelet-rich plasma, we managed to achieve complete healing of diabetic ulcers in 64,2% of patients on day 35 and in 100% of patients on day 42. Conclusion. Local administration of an autologous platelet-rich plasma allows the complete healing of diabetic ulcers in stage 2 with an area of 3–6 cm2 for 6 weeks.

Keywords

• diabetic ulcer
• platelet-rich plasma
• reparation