ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin

Emily Bordeleau; Peter J. Stogios; Elena Evdokimova; Kalinka Koteva; Alexei Savchenko; Gerard D. Wright

doi:10.1128/mBio.02705-20

mBio (Feb 2021)

ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin

Emily Bordeleau,
Peter J. Stogios,
Elena Evdokimova,
Kalinka Koteva,
Alexei Savchenko,
Gerard D. Wright

Affiliations

Emily Bordeleau: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Peter J. Stogios: Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
Elena Evdokimova: Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
Kalinka Koteva: David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Alexei Savchenko: ORCiD; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
Gerard D. Wright: ORCiD; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

DOI: https://doi.org/10.1128/mBio.02705-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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Apramycin is an aminoglycoside antibiotic that has been traditionally used in veterinary medicine. Recently, it has become an attractive candidate to repurpose in the fight against multidrug-resistant pathogens prioritized by the World Health Organization.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal