Revista Brasileira de Epidemiologia (Jun 2008)

Soroprevalência e fatores associados à infecção pelo Helicobacter pylori em doadores de medula óssea de São Paulo Seroprevalence and epidemiological aspects of Helicobacter pylori infection in bone marrow donors in São Paulo

  • Carmen Silvia Vieitas Vergueiro,
  • Ricardo Cordiolli,
  • Daniel Martucci,
  • Valdirene Peres,
  • Andreia Roberta Kiyamu,
  • Karina de Cássia Braga Ribeiro,
  • Carlos Sérgio Chiattone

DOI
https://doi.org/10.1590/S1415-790X2008000200002
Journal volume & issue
Vol. 11, no. 2
pp. 196 – 203

Abstract

Read online

OBJETIVOS: Estimar a prevalência da infecção pelo Helicobacter pylori (HP) e determinar os fatores associados, em adultos saudáveis, doadores voluntários de medula óssea em São Paulo, Brasil. MÉTODOS: 248 indivíduos saudáveis, residentes na zona urbana de São Paulo, responderam a um questionário relatando condições sociais e domiciliares na infância e na vida adulta, assim como antecedentes gastrintestinais e principais fatores associados à infecção. Amostras de sangue foram coletadas e o soro foi analisado utilizando um teste de ELISA previamente validado. RESULTADOS: A prevalência da infecção pelo HP em 248 doadores foi de 48,8%, IC95%= [45,6; 52,0]. Na análise univariada, a infecção pelo HP esteve significativamente associada à ausência de água encanada (p=0,040), a escolaridade da mãe (p=0,005) e do indivíduo (pOBJECTIVES: The purpose of this study was to estimate the prevalence of Helicobacter pylori (HP) infection and evaluate symptoms and factors associated with HP infection in bone marrow donors, in São Paulo, Brazil. METHODS: 248 healthy individuals from urban sites of São Paulo, answered a questionnaire on social and housing conditions in childhood and adult life, as well as clinical gastrointestinal background and main risk factors. Blood samples were collected and serum was tested using a validated ELISA assay. RESULTS: HP prevalence was 48.8%, 95% CI=[45.6; 52.0]. In the univariate analysis, significant associations were found between HP seroprevalence and water supply (p=0.040), maternal (p=0.005) and individual education (p<0.001). Multiple analysis has shown that maternal and individual education were independent risk factors for the infection. CONCLUSIONS: The results have shown that São Paulo's urban sites provided with water supply and sewage systems have similar HP prevalence as industrialized countries. The main risk factors for HP infection were maternal and individual education, which suggests that hygiene and personal habits are determinant to the infection.

Keywords