Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies

David A. Garber; Debra R. Adams; Patricia Guenthner; James Mitchell; Kristen Kelley; Till Schoofs; Anna Gazumyan; Martha Nason; Michael S. Seaman; Janet McNicholl; Michel C. Nussenzweig; Walid Heneine

doi:10.1038/s41467-020-16928-9

Nature Communications (Jun 2020)

Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies

David A. Garber,
Debra R. Adams,
Patricia Guenthner,
James Mitchell,
Kristen Kelley,
Till Schoofs,
Anna Gazumyan,
Martha Nason,
Michael S. Seaman,
Janet McNicholl,
Michel C. Nussenzweig,
Walid Heneine

Affiliations

David A. Garber: Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention
Debra R. Adams: Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention
Patricia Guenthner: Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention
James Mitchell: Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention
Kristen Kelley: Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention
Till Schoofs: Laboratory of Molecular Immunology, The Rockefeller University
Anna Gazumyan: Laboratory of Molecular Immunology, The Rockefeller University
Martha Nason: Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Michael S. Seaman: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Janet McNicholl: Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention
Michel C. Nussenzweig: Laboratory of Molecular Immunology, The Rockefeller University
Walid Heneine: Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention

DOI: https://doi.org/10.1038/s41467-020-16928-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Here, using a repeat-exposure penile SHIV infection model in macaques, the authors show that a single subcutaneous administration of a broadly neutralizing antibody (bNAb) exerts long-acting protection against both penile and vaginal virus exposure, which highlights bNAbs as a potential therapeutic for LA-PrEP.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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