Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies

Abstract

Here, using a repeat-exposure penile SHIV infection model in macaques, the authors show that a single subcutaneous administration of a broadly neutralizing antibody (bNAb) exerts long-acting protection against both penile and vaginal virus exposure, which highlights bNAbs as a potential therapeutic for LA-PrEP.