Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Abstract

Using a Streptococcus pneumoniae human challenge model, the authors here show that baseline nasal microbiota profiles are associated with pneumococcal acquisition and density, independent of live-attenuated influenza vaccine (LAIV) administration, and with mucosal cytokine responses to LAIV.