Materials (Feb 2021)
Whither Magnetic Hyperthermia? A Tentative Roadmap
- Irene Rubia-Rodríguez,
- Antonio Santana-Otero,
- Simo Spassov,
- Etelka Tombácz,
- Christer Johansson,
- Patricia De La Presa,
- Francisco J. Teran,
- María del Puerto Morales,
- Sabino Veintemillas-Verdaguer,
- Nguyen T. K. Thanh,
- Maximilian O. Besenhard,
- Claire Wilhelm,
- Florence Gazeau,
- Quentin Harmer,
- Eric Mayes,
- Bella B. Manshian,
- Stefaan J. Soenen,
- Yuanyu Gu,
- Ángel Millán,
- Eleni K. Efthimiadou,
- Jeff Gaudet,
- Patrick Goodwill,
- James Mansfield,
- Uwe Steinhoff,
- James Wells,
- Frank Wiekhorst,
- Daniel Ortega
Affiliations
- Irene Rubia-Rodríguez
- IMDEA Nanoscience, Faraday 9, 28049 Madrid, Spain
- Antonio Santana-Otero
- IMDEA Nanoscience, Faraday 9, 28049 Madrid, Spain
- Simo Spassov
- Geophysical Centre of the Royal Meteorological Institute, 1 rue du Centre Physique, 5670 Dourbes, Belgium
- Etelka Tombácz
- Soós Water Technology Research and Development Center, University of Pannonia, 8200 Nagykanizsa, Hungary
- Christer Johansson
- RISE Research Institutes of Sweden, Sensors and Materials, Arvid Hedvalls Backe 4, 411 33 Göteborg, Sweden
- Patricia De La Presa
- Instituto de Magnetismo Aplicado UCM-ADIF-CSIC, A6 22,500 km, 29260 Las Rozas, Spain
- Francisco J. Teran
- IMDEA Nanoscience, Faraday 9, 28049 Madrid, Spain
- María del Puerto Morales
- Department of Energy, Environment and Health, Instituto de Ciencia de Materiales de Madrid (ICMM/CSIC), Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain
- Sabino Veintemillas-Verdaguer
- Department of Energy, Environment and Health, Instituto de Ciencia de Materiales de Madrid (ICMM/CSIC), Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain
- Nguyen T. K. Thanh
- UCL Healthcare Biomagnetics and Nanomaterials Laboratories, 21 Albemarle Street, London W1S 4BS, UK
- Maximilian O. Besenhard
- Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK
- Claire Wilhelm
- Laboratoire Matière et Systèmes Complexes MSC, Université de Paris/CNRS, 75013 Paris, France
- Florence Gazeau
- Laboratoire Matière et Systèmes Complexes MSC, Université de Paris/CNRS, 75013 Paris, France
- Quentin Harmer
- Endomag, The Jeffreys Building, St John’s Innovation Park, Cowley Road, Cambridge CB4 0WS, UK
- Eric Mayes
- Endomag, The Jeffreys Building, St John’s Innovation Park, Cowley Road, Cambridge CB4 0WS, UK
- Bella B. Manshian
- Biomedical Sciences Group, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, 3000 Leuven, Belgium
- Stefaan J. Soenen
- Biomedical Sciences Group, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, 3000 Leuven, Belgium
- Yuanyu Gu
- INMA Instituto de Nanociencia de Materiales de Aragón, Pedro Cerbuna 12, 50009 Zaragoza, Spain
- Ángel Millán
- INMA Instituto de Nanociencia de Materiales de Aragón, Pedro Cerbuna 12, 50009 Zaragoza, Spain
- Eleni K. Efthimiadou
- Chemistry Department, Inorganic Chemistry Laboratory, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
- Jeff Gaudet
- Magnetic Insight, Alameda, CA 94501, USA
- Patrick Goodwill
- Magnetic Insight, Alameda, CA 94501, USA
- James Mansfield
- Magnetic Insight, Alameda, CA 94501, USA
- Uwe Steinhoff
- Physikalisch-Technische Bundesanstalt, Abbestraße 2-12, 10587 Berlin, Germany
- James Wells
- Physikalisch-Technische Bundesanstalt, Abbestraße 2-12, 10587 Berlin, Germany
- Frank Wiekhorst
- Physikalisch-Technische Bundesanstalt, Abbestraße 2-12, 10587 Berlin, Germany
- Daniel Ortega
- IMDEA Nanoscience, Faraday 9, 28049 Madrid, Spain
- DOI
- https://doi.org/10.3390/ma14040706
- Journal volume & issue
-
Vol. 14,
no. 4
p. 706
Abstract
The scientific community has made great efforts in advancing magnetic hyperthermia for the last two decades after going through a sizeable research lapse from its establishment. All the progress made in various topics ranging from nanoparticle synthesis to biocompatibilization and in vivo testing have been seeking to push the forefront towards some new clinical trials. As many, they did not go at the expected pace. Today, fruitful international cooperation and the wisdom gain after a careful analysis of the lessons learned from seminal clinical trials allow us to have a future with better guarantees for a more definitive takeoff of this genuine nanotherapy against cancer. Deliberately giving prominence to a number of critical aspects, this opinion review offers a blend of state-of-the-art hints and glimpses into the future of the therapy, considering the expected evolution of science and technology behind magnetic hyperthermia.
Keywords
- magnetic hyperthermia
- magnetic nanoparticles
- hysteresis losses
- cancer
- magnetic particle imaging
- theranostics