Nature Communications (Nov 2021)
Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
Abstract
Installation of difluoroalkyl groups while also imparting stereochemical information is mostly only possible with organocatalytic methods that activate carbonyls. Here the authors show a method to perform an difluoroallylation of hydrazones, forming a masked amine stereocenter, via palladium- and N-heterocyclic-carbene catalysis.