Nature Communications (Nov 2021)

Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand

  • Shuai Huang,
  • Fei-Fei Tong,
  • Da-Chang Bai,
  • Gao-Peng Zhang,
  • Yang-Jie Jiang,
  • Bo Zhang,
  • Xuebing Leng,
  • Ying-Long Guo,
  • Xiao-Long Wan,
  • Xingang Zhang,
  • Chang-Hua Ding,
  • Xue-Long Hou

DOI
https://doi.org/10.1038/s41467-021-26667-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Installation of difluoroalkyl groups while also imparting stereochemical information is mostly only possible with organocatalytic methods that activate carbonyls. Here the authors show a method to perform an difluoroallylation of hydrazones, forming a masked amine stereocenter, via palladium- and N-heterocyclic-carbene catalysis.