Nature Communications (Mar 2020)

Bisphosphonate nanoclay edge-site interactions facilitate hydrogel self-assembly and sustained growth factor localization

  • Yang-Hee Kim,
  • Xia Yang,
  • Liyang Shi,
  • Stuart A. Lanham,
  • Jons Hilborn,
  • Richard O. C. Oreffo,
  • Dmitri Ossipov,
  • Jonathan I. Dawson

DOI
https://doi.org/10.1038/s41467-020-15152-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Nanoclays have been used in composites and for drug delivery but have suffered from a trade-off in properties when used for both. Here the authors report on the use of bisphosphonate interactions with nanoclay edges to made drug loaded composites without compromising materials properties or drug loading.