Elucidating the Role of the NLRP3 Inflammasome in Renal Interstitial Fibrosis Development within Diabetic Nephropathy Contexts

Abstract

Renal interstitial fibrosis (RIF) is a crucial and irreversible element that speeds up the advancement of diabetic nephropathy (DN) to end-stage renal disease. DN-RIF, which is mostly caused by long-lasting inflammation, is greatly affected by the NOD-like receptor thermal protein domainassociated protein 3 (NLRP3) inflammasome. This inflammasome plays a crucial role in triggering inflammatory reactions. The inflammasome has a significant impact in worsening DN-RIF by triggering processes related to inflammation, oxidative stress, and autophagy. This paper thoroughly analyzes the role of the NLRP3 inflammasome in the development of RIF and explores the possibility of traditional Chinese medicine in specifically targeting this inflammasome to reduce the severity of RIF. The primary objective is to promote progress in treatment approaches for the management of recurrent RIF.

Keywords

• nod-like receptor thermal protein domain associated protein 3
• diabetic nephropathy
• renal interstitial fibrosis
• inflammatory