Kindlin-2 links mechano-environment to proline synthesis and tumor growth

Ling Guo; Chunhong Cui; Kuo Zhang; Jiaxin Wang; Yilin Wang; Yixuan Lu; Ka Chen; Jifan Yuan; Guozhi Xiao; Bin Tang; Ying Sun; Chuanyue Wu

doi:10.1038/s41467-019-08772-3

Nature Communications (Feb 2019)

Kindlin-2 links mechano-environment to proline synthesis and tumor growth

Ling Guo,
Chunhong Cui,
Kuo Zhang,
Jiaxin Wang,
Yilin Wang,
Yixuan Lu,
Ka Chen,
Jifan Yuan,
Guozhi Xiao,
Bin Tang,
Ying Sun,
Chuanyue Wu

Affiliations

Ling Guo: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Chunhong Cui: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Kuo Zhang: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Jiaxin Wang: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Yilin Wang: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Yixuan Lu: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Ka Chen: Department of Pathology, University of Pittsburgh School of Medicine
Jifan Yuan: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Guozhi Xiao: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Bin Tang: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Ying Sun: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology and Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology
Chuanyue Wu: Department of Pathology, University of Pittsburgh School of Medicine

DOI: https://doi.org/10.1038/s41467-019-08772-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 20

Abstract

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The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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