Research progress of impaired cerebral hemodynamics in cerebral small vessel disease

Abstract

Cerebral hemodynamic damage is an important mechanism in the pathogenesis of arteriolosclerotic cerebral small vessel disease (CSVD). The hemodynamic damage of cerebral small vessel disease includes the changes of blood pressure variability (BPV), vascular pulsatility, cerebral blood flow (CBF) and so on. Impaired cerebral hemodynamics may promote the progression of the disease by aggravating the damage of endothelial dysfunction and the disruption of blood⁃brain barrier (BBB). This paper reviews progress of impaired cerebral hemodynamics in arteriolosclerotic cerebral small vessel disease.

Keywords

• cerebral small vessel diseases
• hemodynamics
• review