EVALUATION OF THE ADAPTIVE RESPONSE AND NON-SPECIFIC REACTIVITY OF THE HOST IN TUBERCULOSISEXUDATIVE PLEURISY PATIENTS

Abstract

The objective of the study: to evaluate non-specific reactivity of the host based on the adaptive response, its impact on the clinical and morphological manifestations and efficiency of treatment of tuberculous exudative pleurisy.Materials and methods. The non-specific reactivity of 237 tuberculosis exudative pleurisy patients and its correlation with clinical and morphological manifestations and treatment efficiency were investigated as per methods developed by L.Kh. Garkavi and modified by N.A. Brazhenko (2006).Results. It was found out that tuberculosis pleurisy patients had significant disorders of non-specific reactivity by the moment when they were admitted to the in-patient unit: 59% of cases demonstrated compromised adaptive response and 80% had abnormal types of reactivity. Caseous necrotic changes were detected in punctual biopsy specimens more often in case of compromised response versus the normal one (43.8 and 23.6%, p < 0.05). When compared to those with the adequate response, the patients with abnormal reactivity had more disseminated and severe clinical forms of pulmonary tuberculosis with concurrent pleurisy, tuberculous mycobacteria were confidently more often detected in sputum (32.79 versus 17.39%, p < 0.05), and tuberculous inflammation was manifested through more frequent caseous necrotic changes (41.05 versus 17.24% , p < 0.05), and treatment efficiency was lower.

Keywords

• туберкулезный плеврит
• биопсия плевры
• адаптационные реакции
• типы реактивности
• эффективность лечения