Three-component synthesis of new γ-butyrolactones

Abstract

In this research, γ –butyrolactones were prepared using a green, mild, effective and simple method through multi-component synthesis of pyrazole carbaldehyde or indole-3-carbaldehyde, ethylpyruvate and N-bromosuccinimide. The mechanistical pathway for this reaction includes bromination reaction, condensation reaction followed by intra-molecular cyclization. This methodology is completely new and the products were synthesized in short reaction times and high yields. This protocole has advantages as simple method, aqeous media, and reduced environmentally consequences. All of the synthesized compounds were characterized by melting points, infra-red spectroscopy, nuclear magnetic resonance (1H NMR, 13C NMR) and elemental analysis. The novelty of this protocole combined with the novelty of the synthesized compounds is the other highlights of this procedure.

Keywords

• multicomponent reaction
• γ- butyrolactone
• ethylpyruvate
• n-bromosuccinimide