The Stability of Gene Selection in Microarray Experiments

Abstract

This paper addresses the issue of the stability of lists of genes identified as differentially expressed in microarray experiments. The similarities be- tween gene rankings yielded by various gene selection methods performed with resampled datasets were assessed. The mean percentage of overlapping genes for two rankings varied from 10 to 90% depending on the applied gene selection method and the size of the list. The assessment of the stability of obtained gene rankings seems to be relevant in the analysis of microarray data.