Effects of infection history on dengue virus infection and pathogenicity

Tim K. Tsang; Samson L. Ghebremariam; Lionel Gresh; Aubree Gordon; M. Elizabeth Halloran; Leah C. Katzelnick; Diana Patricia Rojas; Guillermina Kuan; Angel Balmaseda; Jonathan Sugimoto; Eva Harris; Ira M. Longini; Yang Yang

doi:10.1038/s41467-019-09193-y

Nature Communications (Mar 2019)

Effects of infection history on dengue virus infection and pathogenicity

Tim K. Tsang,
Samson L. Ghebremariam,
Lionel Gresh,
Aubree Gordon,
M. Elizabeth Halloran,
Leah C. Katzelnick,
Diana Patricia Rojas,
Guillermina Kuan,
Angel Balmaseda,
Jonathan Sugimoto,
Eva Harris,
Ira M. Longini,
Yang Yang

Affiliations

Tim K. Tsang: Department of Biostatistics, College of Public Health and Health Professions, University of Florida
Samson L. Ghebremariam: Department of Biostatistics, College of Public Health and Health Professions, University of Florida
Lionel Gresh: Sustainable Sciences Institute
Aubree Gordon: Department of Epidemiology, School of Public Health, University of Michigan
M. Elizabeth Halloran: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center
Leah C. Katzelnick: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California
Diana Patricia Rojas: Department of Biostatistics, College of Public Health and Health Professions, University of Florida
Guillermina Kuan: Centro de Salud Sócrates Flores Vivas, Ministry of Health
Angel Balmaseda: Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health
Jonathan Sugimoto: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center
Eva Harris: Division of Infectious Diseases and Vaccinology, School of Public Health, University of California
Ira M. Longini: Department of Biostatistics, College of Public Health and Health Professions, University of Florida
Yang Yang: Department of Biostatistics, College of Public Health and Health Professions, University of Florida

DOI: https://doi.org/10.1038/s41467-019-09193-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Lack of knowledge of individual infection history hinders understanding of immunological interactions among DENV serotypes. Here, the authors introduce a framework to infer the relationship between unobserved infection history and subsequent infection and disease risk, and find complex dependencies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal