Nature Communications (Jun 2021)
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection
- Adela S. Oliva Chávez,
- Xiaowei Wang,
- Liron Marnin,
- Nathan K. Archer,
- Holly L. Hammond,
- Erin E. McClure Carroll,
- Dana K. Shaw,
- Brenden G. Tully,
- Amanda D. Buskirk,
- Shelby L. Ford,
- L. Rainer Butler,
- Preeti Shahi,
- Kateryna Morozova,
- Cristina C. Clement,
- Lauren Lawres,
- Anya J. O’ Neal,
- Choukri Ben Mamoun,
- Kathleen L. Mason,
- Brandi E. Hobbs,
- Glen A. Scoles,
- Eileen M. Barry,
- Daniel E. Sonenshine,
- Utpal Pal,
- Jesus G. Valenzuela,
- Marcelo B. Sztein,
- Marcela F. Pasetti,
- Michael L. Levin,
- Michail Kotsyfakis,
- Steven M. Jay,
- Jason F. Huntley,
- Lloyd S. Miller,
- Laura Santambrogio,
- Joao H. F. Pedra
Affiliations
- Adela S. Oliva Chávez
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Xiaowei Wang
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Liron Marnin
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Nathan K. Archer
- Department of Dermatology, Johns Hopkins University School of Medicine
- Holly L. Hammond
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Erin E. McClure Carroll
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Dana K. Shaw
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Brenden G. Tully
- Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences
- Amanda D. Buskirk
- Center for Vaccine Development and Global Health, University of Maryland School of Medicine
- Shelby L. Ford
- Centers for Disease Control and Prevention
- L. Rainer Butler
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Preeti Shahi
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Kateryna Morozova
- Department of Pathology, Albert Einstein College of Medicine
- Cristina C. Clement
- Department of Pathology, Albert Einstein College of Medicine
- Lauren Lawres
- Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine
- Anya J. O’ Neal
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Choukri Ben Mamoun
- Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine
- Kathleen L. Mason
- USDA, ARS, Animal Disease Research Unit, Washington State University
- Brandi E. Hobbs
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- Glen A. Scoles
- USDA, ARS, Animal Disease Research Unit, Washington State University
- Eileen M. Barry
- Center for Vaccine Development and Global Health, University of Maryland School of Medicine
- Daniel E. Sonenshine
- Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Utpal Pal
- Department of Veterinary Medicine, University of Maryland
- Jesus G. Valenzuela
- Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Marcelo B. Sztein
- Center for Vaccine Development and Global Health, University of Maryland School of Medicine
- Marcela F. Pasetti
- Center for Vaccine Development and Global Health, University of Maryland School of Medicine
- Michael L. Levin
- Centers for Disease Control and Prevention
- Michail Kotsyfakis
- Institute of Parasitology, Biology Center of the Czech Academy of Sciences
- Steven M. Jay
- Fischell Department of Bioengineering, University of Maryland
- Jason F. Huntley
- Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences
- Lloyd S. Miller
- Department of Dermatology, Johns Hopkins University School of Medicine
- Laura Santambrogio
- Department of Microbiology and Immunology, Albert Einstein College of Medicine
- Joao H. F. Pedra
- Department of Microbiology and Immunology, University of Maryland School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23900-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Extracellular vesicles have been implicated in the transmission of pathogens from the arthropod to the human host. Here the authors show that tick-derived extracellular vesicles play a role in feeding and modulate the outcome of bacterial infection.
