Rare Tumors (Feb 2013)

Primary NK/T cell lymphoma nasal type of the colon

  • Ana María Chirife,
  • Juan Alberto Cicco,
  • Marta Elisa Zerga,
  • Claudia Érica Casali,
  • Mercedes del Olmo,
  • María de los Ángeles Vicente Repáraz,
  • Gonzalo Martín Garate,
  • Carolina Valeria Mahuad,
  • Erica Rojas Bilbao

DOI
https://doi.org/10.4081/rt.2013.e9
Journal volume & issue
Vol. 5, no. 1
pp. e9 – e9

Abstract

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Since nasal NK/T-cell lymphoma and NK/T-cell lymphoma nasal type are rare diseases, colonic involvement has seldom been seen. We report a case of a patient with a primary NK/T-cell lymphoma nasal type of the colon. The patient had no history of malignant diseases and was diagnosed after exhaustive study in the context of fever of unknown origin. The first therapeutic approach followed the DAEPOCH-protocol: etoposide, prednisone, doxor-rubicin, vincristine and cyclophosphamide. The persistence of constitutional symptoms after the first treatment course motivated the switch to a second line following the SMILE-protocol: dexamethasone, metotrexate, ifosfamide, E.coli L-asparaginase, and etoposide. Despite intensive chemotherapy, the patient died 2 months after the diagnose of an extranodal NK/T-cell lymphoma of the colon and 4 months after the first symptomatic appearance of disease.

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