Nature Communications (Apr 2022)
Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma
- Congyi Lu,
- Akanksha Mahajan,
- Sung-Hyeok Hong,
- Susana Galli,
- Shiya Zhu,
- Jason U. Tilan,
- Nouran Abualsaud,
- Mina Adnani,
- Stacey Chung,
- Nada Elmansy,
- Jasmine Rodgers,
- Olga Rodriguez,
- Christopher Albanese,
- Hongkun Wang,
- Maureen Regan,
- Valerie Zgonc,
- Jan Blancato,
- Ewa Krawczyk,
- G. Ian Gallicano,
- Michael Girgis,
- Amrita Cheema,
- Ewa Iżycka-Świeszewska,
- Luciane R. Cavalli,
- Svetlana D. Pack,
- Joanna Kitlinska
Affiliations
- Congyi Lu
- Department of Physiology and Biophysics, Georgetown University
- Akanksha Mahajan
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- Sung-Hyeok Hong
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- Susana Galli
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- Shiya Zhu
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- Jason U. Tilan
- Department of Human Science, School of Nursing and Health Studies, Georgetown University
- Nouran Abualsaud
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- Mina Adnani
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- Stacey Chung
- Department of Human Science, School of Nursing and Health Studies, Georgetown University
- Nada Elmansy
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- Jasmine Rodgers
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- Olga Rodriguez
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Christopher Albanese
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Hongkun Wang
- Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University
- Maureen Regan
- Genome Editing Core, University of Illinois
- Valerie Zgonc
- Laboratory of Pathology, National Cancer Institute, National Institutes of Health
- Jan Blancato
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Ewa Krawczyk
- Center for Cell Reprogramming, Georgetown University Medical Center
- G. Ian Gallicano
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- Michael Girgis
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Amrita Cheema
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Ewa Iżycka-Świeszewska
- Department of Pathology and Neuropathology, Medical University of Gdańsk
- Luciane R. Cavalli
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Svetlana D. Pack
- Laboratory of Pathology, National Cancer Institute, National Institutes of Health
- Joanna Kitlinska
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-29898-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Ewing sarcoma tumour cells frequently metastasize to the bone but the molecular mechanisms governing this process are not well understood. Here, the authors show that neuropeptide Y/Y5 receptor pathway is activated in the hypoxic tumour microenvironment, which results in cytokinesis defects and chromosomal instability, leading to bone invasion.
