FEATURES OF HEMODYNAMICS IN THE TESTICLES AND SPERMATOGENESIS IN BRONCHIAL ASTHMA

Abstract

The characteristics of hemodynamics and structural and functional changes in the testicles and ejaculate of infertile men of mature age with bronchial asthma were studied. The methods of ultrasound scanning, color ultrasound angiography, histology, morphometry, laboratory diagnosis of ejaculate and statistics were used. Using the method of ultrasound scanning and color ultrasound angiography of the testicles, the volume of the testicles and such hemodynamic parameters as peak arterial blood flow, diastolic blood flow, average blood flow and volumetric blood flow were determined in 15 infertile men. In the urological department of the communal noncommercial enterprise «Regional Clinical Hospital of the Ivano-Frankivsk Regional Council» the histostructure of the testicles was examined in 7 testicular biopsies with this pathology, and the concentration of spermatozoa, their morphological form and motility in the ejaculate according to the generally accepted method. The concentration of testosterone in the blood was studied by enzyme immunoassay using an analytical analyzer IMMULITE–2000 (Siemens Healthcare Diagnostics Inc., США). It was found that under these conditions, the volume of the testicles decreases to (15.30±1.45) cm3 against (19.60±0.70) cm3 . The maximum blood flow velocity in the testicular artery within the spermatic cord decreases to (13.9±0.7) cm/s against (19.0±1.5) cm/s in men of the control group, and the average minimum blood flow velocity is to (5.7±0.2) cm/s, versus (8.2±1.0) cm/s, respectively. The volumetric blood flow in the testicular artery decreases to (8.3±0.7) ml/s against (16.5±1.2) ml/s in the control. The average linear velocity of blood flow in the testicular veins decreases to (6.9±0.4) cm/s, and the volumetric blood flow velocity in them to (5.9±0.1) ml/min against (8.0± 0.2) cm/s in control. In testicular biopsies with this pathology, the diameter of convoluted seminiferous tubules decreases to (160.8±5.3) μm, against (190.6±5.4) μm in the control. 1–2 layers of spermatogonia and spermatocytes are adjacent to the thickened own shell of convoluted seminiferous tubules. The concentration of spermatozoa in the ejaculate of men decreases to (25.30±4.60) million/ml, against (73.5±3.60) million/ml. The number of spermatozoa with pathology of the head increases to (20.18±3.50)%, against (11.78±0.36)% in the control, and the number of spermatozoa with pathology of the main part of the flagellum to (18.60±3.50)% against (9.06±0.43)%. The level of testosterone in the blood decreases to (330.50±10.70) ng/dL, against (780.30±21.40) ng/dL in men of the control group.

Keywords

• testicle,hemodynamics,spermatogenesis,bronchial asthma.