The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer

Hao-fan Wang; Sha-sha Wang; Ya-Jie Tang; Yu Chen; Min Zheng; Ya-ling Tang; Xin-hua Liang

doi:10.3389/fimmu.2019.00653

Frontiers in Immunology (Apr 2019)

The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer

Hao-fan Wang,
Sha-sha Wang,
Ya-Jie Tang,
Yu Chen,
Min Zheng,
Ya-ling Tang,
Xin-hua Liang

Affiliations

Hao-fan Wang: State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China
Sha-sha Wang: State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China
Ya-Jie Tang: Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, Wuhan, China
Yu Chen: State Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China
Min Zheng: Department of Stomatology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, China
Ya-ling Tang: State Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China
Xin-hua Liang: State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China

DOI: https://doi.org/10.3389/fimmu.2019.00653
Journal volume & issue: Vol. 10

Abstract

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Patients with human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have remarkably better prognosis, which differs from HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) with respect to clinical, genomic, molecular, and immunological aspects, especially having the characteristics of high levels of immune cell infiltration and high degrees of immunosuppression. This review will summarize immune evasion mechanisms in HPV-positive HNSCC, analyze the host various immune responses to HPV and abundant numbers of infiltrating immune cell, and discuss the differences between HPV-positive HNSCC with cervical cancer. A deeper understanding of the immune landscape will help new concepts to emerge in immune-checkpoint oncology, which might be a valuable add-on to established concepts.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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