Effects of Thinner Inhalation on the Rat Nasal Mucosa

Abstract

People are exposed to volatile substances by inhalation, skin contact or oral intake, because these are widely used in industry. In recent years these substances are abused for their euphoric effects, especially thinner. Among these substances, thinner is the choice of the young people with low socioeconomic level and familial problems due to the expense, hardness to find and illegality of other drugs. In addition, many more are unwillingly exposed to these substances at work. So it’s becoming more important to find out the effects of thinner inhalation on nasal mucosa. This experimental study was performed to evaluate the effects of thinner on the nasal mucosa. Four groups were dispersed due to inhalation periods. Exposure periods of the first, second, third and fourth groups were 1 week, 3 weeks, 4 weeks and 5 weeks respectively. Thinner inhaled animals lost weight within weeks. Loss of weight in the third group was found to be statistically significant compared to other groups and controls (p0.05). Squamous metaplasia, epithelial stratification and budding were formed by the first week; but no statistically significant increase was detected till the end of the 5th week (p>0.05). Epithelial villous hypertrophy appeared in the second group and became significantly prominent during following weeks in other groups as well (p<0.01). In conclusion, villous formations, budding, stratifications which are different forms of epithelial hyperplasia; and squamous metaplasia were observed in the nasal mucosa which exposed to thinner. So it was shown that thinner is harmful for the nasal mucosa as well as for the other organs of the respiratory system.

Keywords

• thinner
• nasal mucosa
• toxicity.