Nature Communications (Feb 2019)

Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide

  • Sonu Kumar,
  • Anita Sarkar,
  • Pavel Pugach,
  • Rogier W. Sanders,
  • John P. Moore,
  • Andrew B. Ward,
  • Ian A. Wilson

DOI
https://doi.org/10.1038/s41467-019-08738-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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The fusion peptide (FP) of HIV envelope (Env) is critical in the cell entry process. Here, Kumar et al. present crystal structures of B41 SOSIP.664 Env trimer and show the dynamic nature of the FP and proximal region, which likely relates to conformational rearrangements required for membrane fusion.