Nature Communications (Jul 2016)
Deconvoluting hepatic processing of carbon nanotubes
- Simone Alidori,
- Robert L. Bowman,
- Dmitry Yarilin,
- Yevgeniy Romin,
- Afsar Barlas,
- J. Justin Mulvey,
- Sho Fujisawa,
- Ke Xu,
- Alessandro Ruggiero,
- Vladimir Riabov,
- Daniel L. J. Thorek,
- Hans David S. Ulmert,
- Elliott J. Brea,
- Katja Behling,
- Julia Kzhyshkowska,
- Katia Manova-Todorova,
- David A. Scheinberg,
- Michael R. McDevitt
Affiliations
- Simone Alidori
- Department of Radiology, Memorial Sloan-Kettering Cancer Center
- Robert L. Bowman
- Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center
- Dmitry Yarilin
- Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center
- Yevgeniy Romin
- Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center
- Afsar Barlas
- Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center
- J. Justin Mulvey
- Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center
- Sho Fujisawa
- Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center
- Ke Xu
- Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center
- Alessandro Ruggiero
- Department of Radiology, Papworth Hospital NHS Foundation Trust, Cambridge University Health Partners
- Vladimir Riabov
- Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Ruprecht-Karls University of Heidelberg
- Daniel L. J. Thorek
- Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine
- Hans David S. Ulmert
- Department of Radiology, Memorial Sloan-Kettering Cancer Center
- Elliott J. Brea
- Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center
- Katja Behling
- Department of Radiology, Memorial Sloan-Kettering Cancer Center
- Julia Kzhyshkowska
- Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Ruprecht-Karls University of Heidelberg
- Katia Manova-Todorova
- Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center
- David A. Scheinberg
- Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center
- Michael R. McDevitt
- Department of Radiology, Memorial Sloan-Kettering Cancer Center
- DOI
- https://doi.org/10.1038/ncomms12343
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
Application of carbon nanotubes as drug delivery carriers is stalled by uncertainties over their distribution and toxicity in vivo. Here, the authors use animal models to show that, while the bulk of nanotubes is renally cleared, a fraction can be eliminated through an alternative hepatobiliary pathway.
