Nature Communications (Oct 2021)
CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
- Enja Schneider,
- Riekje Winzer,
- Anne Rissiek,
- Isabell Ricklefs,
- Catherine Meyer-Schwesinger,
- Franz L. Ricklefs,
- Andreas Bauche,
- Jochen Behrends,
- Rudolph Reimer,
- Santra Brenna,
- Hauke Wasielewski,
- Melchior Lauten,
- Björn Rissiek,
- Berta Puig,
- Filippo Cortesi,
- Tim Magnus,
- Ralf Fliegert,
- Christa E. Müller,
- Nicola Gagliani,
- Eva Tolosa
Affiliations
- Enja Schneider
- Department of Immunology, University Medical Center Hamburg-Eppendorf
- Riekje Winzer
- Department of Immunology, University Medical Center Hamburg-Eppendorf
- Anne Rissiek
- Department of Immunology, University Medical Center Hamburg-Eppendorf
- Isabell Ricklefs
- Division of Pediatric Pneumology & Allergology, University Medical Center Schleswig-Holstein
- Catherine Meyer-Schwesinger
- Department of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf
- Franz L. Ricklefs
- Department of Neurosurgery, University Medical Center Hamburg-Eppendorf
- Andreas Bauche
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Jochen Behrends
- Core Facility Fluorescence Cytometry, Research Center Borstel
- Rudolph Reimer
- Technology Platform Microscopy and Image Analysis, Heinrich Pette Institute/Leibniz Institute for Experimental Virology
- Santra Brenna
- Department of Neurology, University Medical Center Hamburg-Eppendorf
- Hauke Wasielewski
- Department of Immunology, University Medical Center Hamburg-Eppendorf
- Melchior Lauten
- Department of Pediatrics and Adolescent Medicine, University of Lübeck
- Björn Rissiek
- Department of Neurology, University Medical Center Hamburg-Eppendorf
- Berta Puig
- Department of Neurology, University Medical Center Hamburg-Eppendorf
- Filippo Cortesi
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Tim Magnus
- Department of Neurology, University Medical Center Hamburg-Eppendorf
- Ralf Fliegert
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Christa E. Müller
- Department of Pharmaceutical & Medicinal Chemistry, University of Bonn
- Nicola Gagliani
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Eva Tolosa
- Department of Immunology, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-021-26134-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Ectonucleotidases associated to regulatory T cells are known modulators in the inflammatory environment. Here the authors describe CD8 T cell-derived extracellular vesicles bearing CD73 and suggest they function as an additional intrinsic modulator of immune responses.
