Signal Transduction and Targeted Therapy (Dec 2021)

SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

  • Meng-Li Wu,
  • Feng-Liang Liu,
  • Jing Sun,
  • Xin Li,
  • Xiao-Yan He,
  • Hong-Yi Zheng,
  • Yan-Heng Zhou,
  • Qihong Yan,
  • Ling Chen,
  • Guo-Ying Yu,
  • Junbiao Chang,
  • Xia Jin,
  • Jincun Zhao,
  • Xin-Wen Chen,
  • Yong-Tang Zheng,
  • Jian-Hua Wang

DOI
https://doi.org/10.1038/s41392-021-00849-0
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 15

Abstract

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A schematic illustration of SARS-CoV-2 triggers MC rapid degranulation to induce alveolar epithelial inflammation and lung injury. SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.