Nature Communications (Dec 2020)
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
- Xiaona Sun,
- Ting Liu,
- Jun Zhao,
- Hansong Xia,
- Jun Xie,
- Yu Guo,
- Li Zhong,
- Mi Li,
- Qing Yang,
- Cheng Peng,
- Isabelle Rouvet,
- Alexandre Belot,
- Hong-Bing Shu,
- Pinghui Feng,
- Junjie Zhang
Affiliations
- Xiaona Sun
- The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan University
- Ting Liu
- The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan University
- Jun Zhao
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California
- Hansong Xia
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California
- Jun Xie
- The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan University
- Yu Guo
- The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan University
- Li Zhong
- Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University
- Mi Li
- Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University
- Qing Yang
- Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University
- Cheng Peng
- Department of Burns and Plastic Surgery, 3rd Xiangya Hospital, Central South University
- Isabelle Rouvet
- Hospices Civils de Lyon, Centre de Biotechnologie Cellulaire et Biothèque
- Alexandre Belot
- Centre International de Recherche en Infectiologie, CIRI, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University of Lyon
- Hong-Bing Shu
- Frontier Science Center for Immunology and Metabolism, Medical Research Institute, School of Medicine, Wuhan University
- Pinghui Feng
- Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California
- Junjie Zhang
- The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, State Key Laboratory of Virology, Wuhan University
- DOI
- https://doi.org/10.1038/s41467-020-19941-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.
