Communications Biology (Jul 2022)
MYPT1 reduction is a pathogenic factor of erectile dysfunction
- Wei Zhao,
- Jie Sun,
- Liang-Yu Yao,
- Dong Hang,
- Ye-Qiong Li,
- Cai-Ping Chen,
- Yu-Wei Zhou,
- Xin Chen,
- Tao Tao,
- Li-Sha Wei,
- Yan-Yan Zheng,
- Xie Ge,
- Chao-Jun Li,
- Zhong-Cheng Xin,
- Yang Pan,
- Xin-Zhu Wang,
- Wei-Qi He,
- Xue-Na Zhang,
- Bing Yao,
- Min-Sheng Zhu
Affiliations
- Wei Zhao
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Jie Sun
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Liang-Yu Yao
- Department of Urology, the First Affiliated Hospital of Nanjing Medical University
- Dong Hang
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Ye-Qiong Li
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Cai-Ping Chen
- State Key Laboratory of Natural Medicines, China Pharmaceutical University
- Yu-Wei Zhou
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Xin Chen
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Tao Tao
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Li-Sha Wei
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Yan-Yan Zheng
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Xie Ge
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Chao-Jun Li
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Zhong-Cheng Xin
- Andrology Center, Peking University First Hospital, Peking University
- Yang Pan
- School of Pharmacy, Nanjing University of Chinese Medicine
- Xin-Zhu Wang
- School of Pharmacy, Nanjing University of Chinese Medicine
- Wei-Qi He
- Cambridge-Suda (CAM-SU) Genomic Resource Center, Soochow University
- Xue-Na Zhang
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Bing Yao
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- Min-Sheng Zhu
- Jinling Hospital Department of Reproductive Medical Center affiliated Sch Med, State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University
- DOI
- https://doi.org/10.1038/s42003-022-03716-y
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Reduced expression of myosin phosphatase target subunit 1 (MYPT1) is critical for the development of vasculogenic erectile dysfunction and a natural compound, lotusine, is found to increase MYPT1 expression and rescue penile smooth muscle function.
