Nature Communications (Dec 2019)
Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
- C. E. van de Sandt,
- E. B. Clemens,
- E. J. Grant,
- L. C. Rowntree,
- S. Sant,
- H. Halim,
- J. Crowe,
- A. C. Cheng,
- T. C. Kotsimbos,
- M. Richards,
- A. Miller,
- S. Y. C. Tong,
- J. Rossjohn,
- T. H. O. Nguyen,
- S. Gras,
- W. Chen,
- K. Kedzierska
Affiliations
- C. E. van de Sandt
- Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute
- E. B. Clemens
- Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute
- E. J. Grant
- Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute
- L. C. Rowntree
- Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute
- S. Sant
- Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute
- H. Halim
- Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- J. Crowe
- Deepdene Surgery
- A. C. Cheng
- School of Public Health and Preventive Medicine, Monash University
- T. C. Kotsimbos
- Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital
- M. Richards
- Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity
- A. Miller
- Indigenous Research Network, Griffith University
- S. Y. C. Tong
- Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity
- J. Rossjohn
- Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- T. H. O. Nguyen
- Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute
- S. Gras
- Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- W. Chen
- Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University
- K. Kedzierska
- Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute
- DOI
- https://doi.org/10.1038/s41467-019-13346-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
The HLA-A*68:01 allele has been associated with severe influenza disease during the 2009 influenza pandemic. Here, the authors analyze influenza nucleoprotein specific HLA-A*68:01-restricted CD8+ T cells from human donors and show immunodominance of these cells in approximately 35% of HLA-A*68:01-expressing donors.
