Vascular Health and Risk Management (Dec 2022)
Ventricular Function and Cardio-Ankle Vascular Index in Patients With Pulmonary Artery Hypertension
Abstract
Ganna Dmytrivna Radchenko, Yurii Anatoliiovych Botsiuk, Yuriy Mykolaiyovich Sirenko State Institution “National Scientific Center “The M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Medical Science of Ukraine”, Kyiv, UkraineCorrespondence: Ganna Dmytrivna Radchenko, State Institution National Scientific Center “The M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of the National Academy of Medical Science of Ukraine”, 5, Svyatoslava Khorobroho str., Kyiv, 03151, Ukraine, Tel +38-0667128405, Email [email protected]: Aim: This study aims to evaluate the left ventricle (LV) systolic and diastolic function in patients with idiopathic pulmonary arterial hypertension (IPAH) and its correlation with systemic arterial stiffness assessed by cardio-ankle vascular index (CAVI).Patient and methods: We included 37 patients with IPAH and 20 healthy people matched by age. All patients were assessed: vital signs, 6-minute walk test, NT-proBNP level, the CAVI, the right ventricular (RV) and LV function parameters, including ejection time (ET), tissue speckle-tracking values – global longitudinal strain (GLS) and strain rate (SR).Results: The groups were matched by age, gender, BMI, office SBP and DBP. Patients with IPAH had higher heart rate, NT-proBNP level and lower ferritin level, GFR (CKD-EPI), SaO2 than healthy people. The mean CAVIleft was higher in IPAH patients than in the control group- 8.7± 1.1 vs 7.5± 0.9, P=0.007. Healthy people had significantly less E/e’ and lower IVRT. LVET and RVET were shorter in IPAH patients. Patients with IPAH had mean LVGLS –(− 17.6± 4.8%) and 35.1% of them were with LVGLS ≤ 16% compared to healthy people –(− 21.8± 1.4%) and 0%, respectively. LVSR was significant less in IPAH patients, but in the normal range. We found significant correlations of CAVI with age, history of syncope, bilirubin, uric acid, total cholesterol, cardiac output, cardiac index, RVET, LVET and E/A. Multiple linear regression confirmed the independent significance for age (β=0.083± 0.023, CI 0.033– 0.133) and RVET (β=-0.018± 0.005, CI -0.029 to − 0.008) only. The risk to have CAVI ≥ 8 increased in 5.8 times in IPAH patients with RVET
