A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour

Fan Xu; Xueqian Zhao; Lingli Yang; Xiuhua Wang; Jing Zhao

doi:10.3390/molecules190913422

Molecules (Aug 2014)

A New Cycloartane-Type Triterpenoid Saponin Xanthine Oxidase Inhibitor from Homonoia riparia Lour

Fan Xu,
Xueqian Zhao,
Lingli Yang,
Xiuhua Wang,
Jing Zhao

Affiliations

Fan Xu: Kunming General Hospital of Chengdu Military Region, Kunming 650032, Yunnan, China
Xueqian Zhao: Kunming General Hospital of Chengdu Military Region, Kunming 650032, Yunnan, China
Lingli Yang: The First Affiliated Hospital of Kunming Medical University, Kunming 650031, Yunnan, China
Xiuhua Wang: Kunming General Hospital of Chengdu Military Region, Kunming 650032, Yunnan, China
Jing Zhao: Kunming General Hospital of Chengdu Military Region, Kunming 650032, Yunnan, China

DOI: https://doi.org/10.3390/molecules190913422
Journal volume & issue: Vol. 19, no. 9
pp. 13422 – 13431

Abstract

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A new cycloartane-type triterpenoid saponin named riparsaponin (1) was isolated from the stem of Homonoia riparia Lour together with six known compounds. The structure of riparsaponin was determined by using NMR and mass spectroscopy and X-ray crystallography techniques. Additionally, riparsaponin has a significant inhibitory effect on xanthine oxidase in vitro, and the IC50 was 11.16 nmol/mL.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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