Super-enhancer-associated TTC8 alters the nucleocytoplasmic distribution of PHOX2B and activates MAPK signaling in neuroblastoma

• Ran Zhuo,
• Zimu Zhang,
• Xinyi Guo,
• Haibo Cao,
• Yanling Chen,
• Yanfang Tao,
• Randong Yang,
• Xiaolu Li,
• Jian Pan,
• Jian Wang

Affiliations

Ran Zhuo

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China; Department of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, China

Zimu Zhang

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China

Xinyi Guo

Medical College of Soochow University, Suzhou, Jiangsu 215123, China

Haibo Cao

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China; Department of Pediatrics, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, China

Yanling Chen

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China; School of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215003, China

Yanfang Tao

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China

Randong Yang

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China; Department of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, China

Xiaolu Li

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China

Jian Pan

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China; Corresponding author. Institute of Pediatric Research, Children's Hospital of Soochow University, No.92 Zhongnan Street, Suzhou, Jiangsu 215003, China. Tel.: +86 0512 80692935.

Jian Wang

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China; Department of Pediatric Surgery, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, China; Corresponding author. Department of Pediatric Surgery, Children's Hospital of Soochow University, No.92 Zhongnan Street, Suzhou, Jiangsu 215025, China.