THE ROLE OF ANTIOXYDANT ENZYMES IN PATHOGENESIS OF ARTERIAL HYPERTENSION AT TEENAGERS

Abstract

Purpose: to study antioxidant enzymatic state of rythrocytes at arterial hypertension (AH) at teenagers.Materials and methods: venous blood taken from cubital vein and stabilized by heparin was used for investigation. 20 teenagers from 13 to 16 years was examinated. Main antioxidant enzymes: superoxidedismutase (SOD), catalase, glutathione reductase (GR), glutathione peroxidase (GPO) and level of reductive form of glutathione (GSH) were investigated in the purpose to estimate the state of antioxidant system.Results: teenagers with AH has had dysbalance in the first line of antioxidant system (increasing SOD activity and inhibition of catalase) in combination with more intensive work of second line of antioxidant enzymes (significant activation of GPO).Summary: clinico-biochemical analisis has shown that nonspecific adaptational changes have formed at teenagers that can be included into laboratory algorithms of diagnostic of AH.

Keywords

• arterial hypertension
• teenagers
• antioxidant protection