Nature Communications (Jul 2022)
Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
- Sara Larivière,
- Jessica Royer,
- Raúl Rodríguez-Cruces,
- Casey Paquola,
- Maria Eugenia Caligiuri,
- Antonio Gambardella,
- Luis Concha,
- Simon S. Keller,
- Fernando Cendes,
- Clarissa L. Yasuda,
- Leonardo Bonilha,
- Ezequiel Gleichgerrcht,
- Niels K. Focke,
- Martin Domin,
- Felix von Podewills,
- Soenke Langner,
- Christian Rummel,
- Roland Wiest,
- Pascal Martin,
- Raviteja Kotikalapudi,
- Terence J. O’Brien,
- Benjamin Sinclair,
- Lucy Vivash,
- Patricia M. Desmond,
- Elaine Lui,
- Anna Elisabetta Vaudano,
- Stefano Meletti,
- Manuela Tondelli,
- Saud Alhusaini,
- Colin P. Doherty,
- Gianpiero L. Cavalleri,
- Norman Delanty,
- Reetta Kälviäinen,
- Graeme D. Jackson,
- Magdalena Kowalczyk,
- Mario Mascalchi,
- Mira Semmelroch,
- Rhys H. Thomas,
- Hamid Soltanian-Zadeh,
- Esmaeil Davoodi-Bojd,
- Junsong Zhang,
- Gavin P. Winston,
- Aoife Griffin,
- Aditi Singh,
- Vijay K. Tiwari,
- Barbara A. K. Kreilkamp,
- Matteo Lenge,
- Renzo Guerrini,
- Khalid Hamandi,
- Sonya Foley,
- Theodor Rüber,
- Bernd Weber,
- Chantal Depondt,
- Julie Absil,
- Sarah J. A. Carr,
- Eugenio Abela,
- Mark P. Richardson,
- Orrin Devinsky,
- Mariasavina Severino,
- Pasquale Striano,
- Domenico Tortora,
- Erik Kaestner,
- Sean N. Hatton,
- Sjoerd B. Vos,
- Lorenzo Caciagli,
- John S. Duncan,
- Christopher D. Whelan,
- Paul M. Thompson,
- Sanjay M. Sisodiya,
- Andrea Bernasconi,
- Angelo Labate,
- Carrie R. McDonald,
- Neda Bernasconi,
- Boris C. Bernhardt
Affiliations
- Sara Larivière
- Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University
- Jessica Royer
- Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University
- Raúl Rodríguez-Cruces
- Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University
- Casey Paquola
- Institute for Neuroscience and Medicine (INM-1), Forschungszentrum Jülich
- Maria Eugenia Caligiuri
- Neuroscience Research Center, University Magna Græcia
- Antonio Gambardella
- Neuroscience Research Center, University Magna Græcia
- Luis Concha
- Institute of Neurobiology, Universidad Nacional Autónoma de México
- Simon S. Keller
- Institute of Systems, Molecular and Integrative Biology, University of Liverpool
- Fernando Cendes
- Department of Neurology, University of Campinas–UNICAMP, Campinas
- Clarissa L. Yasuda
- Department of Neurology, University of Campinas–UNICAMP, Campinas
- Leonardo Bonilha
- Department of Neurology, Emory University
- Ezequiel Gleichgerrcht
- Department of Neurology, Medical University of South Carolina
- Niels K. Focke
- Department of Neurology, University of Medicine Göttingen
- Martin Domin
- Institute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald
- Felix von Podewills
- Department of Neurology, University Medicine Greifswald
- Soenke Langner
- Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald
- Christian Rummel
- Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern
- Roland Wiest
- Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern
- Pascal Martin
- Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Raviteja Kotikalapudi
- Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen
- Terence J. O’Brien
- Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne
- Benjamin Sinclair
- Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne
- Lucy Vivash
- Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne
- Patricia M. Desmond
- Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne
- Elaine Lui
- Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne
- Anna Elisabetta Vaudano
- Neurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria
- Stefano Meletti
- Neurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria
- Manuela Tondelli
- Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia
- Saud Alhusaini
- Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland
- Colin P. Doherty
- Department of Neurology, St James’ Hospital
- Gianpiero L. Cavalleri
- Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland
- Norman Delanty
- Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland
- Reetta Kälviäinen
- Epilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network for Rare and Complex Epilepsies EpiCARE
- Graeme D. Jackson
- Florey Institute of Neuroscience and Mental Health, University of Melbourne
- Magdalena Kowalczyk
- Florey Institute of Neuroscience and Mental Health, University of Melbourne
- Mario Mascalchi
- Neuroradiology Research Program, Meyer Children Hospital of Florence, University of Florence
- Mira Semmelroch
- Florey Institute of Neuroscience and Mental Health, University of Melbourne
- Rhys H. Thomas
- Transitional and Clinical Research Institute, Newcastle University
- Hamid Soltanian-Zadeh
- Contol and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran
- Esmaeil Davoodi-Bojd
- Department of Neurology, Henry Ford Health System
- Junsong Zhang
- Cognitive Science Department, Xiamen University
- Gavin P. Winston
- Division of Neurology, Department of Medicine, Queen’s University
- Aoife Griffin
- Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast
- Aditi Singh
- Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast
- Vijay K. Tiwari
- Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast
- Barbara A. K. Kreilkamp
- Department of Neurology, University of Medicine Göttingen
- Matteo Lenge
- Child Neurology Unit and Laboratories, Neuroscience Department, Children’s Hospital A. Meyer-University of Florence
- Renzo Guerrini
- Child Neurology Unit and Laboratories, Neuroscience Department, Children’s Hospital A. Meyer-University of Florence
- Khalid Hamandi
- The Welsh Epilepsy Unit, Department of Neurology, University Hospital of Whales
- Sonya Foley
- Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University
- Theodor Rüber
- Department of Epileptology, University of Bonn Medical Center
- Bernd Weber
- Institute of Experimental Epileptology and Cognition Research, University Hospital Bonn
- Chantal Depondt
- Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles
- Julie Absil
- Department of Radiology, Hôpital Erasme, Université Libre de Bruxelles
- Sarah J. A. Carr
- Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Eugenio Abela
- Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Mark P. Richardson
- Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Orrin Devinsky
- Department of Neurology, NYU Grossman School of Medicine
- Mariasavina Severino
- IRCCS Istituto Giannina Gaslini
- Pasquale Striano
- IRCCS Istituto Giannina Gaslini
- Domenico Tortora
- Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova
- Erik Kaestner
- Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego
- Sean N. Hatton
- Department of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego
- Sjoerd B. Vos
- Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology
- Lorenzo Caciagli
- Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology
- John S. Duncan
- Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology
- Christopher D. Whelan
- Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland
- Paul M. Thompson
- Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California
- Sanjay M. Sisodiya
- Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology
- Andrea Bernasconi
- Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University
- Angelo Labate
- Neurology, BIOMORF Dipartment, University of Messina
- Carrie R. McDonald
- Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego
- Neda Bernasconi
- Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University
- Boris C. Bernhardt
- Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University
- DOI
- https://doi.org/10.1038/s41467-022-31730-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Epilepsy is a brain network disorder with associated genetic risk factors. Here, the authors show that spatial patterns of transcriptomic vulnerability co-vary with structural brain network alterations in focal and generalized epilepsy.
