Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga

Yuqun Xu; Takuya Miyakawa; Shohei Nosaki; Akira Nakamura; Ying Lyu; Hidemitsu Nakamura; Umeharu Ohto; Hanako Ishida; Toshiyuki Shimizu; Tadao Asami; Masaru Tanokura

doi:10.1038/s41467-018-06452-2

Nature Communications (Sep 2018)

Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga

Yuqun Xu,
Takuya Miyakawa,
Shohei Nosaki,
Akira Nakamura,
Ying Lyu,
Hidemitsu Nakamura,
Umeharu Ohto,
Hanako Ishida,
Toshiyuki Shimizu,
Tadao Asami,
Masaru Tanokura

Affiliations

Yuqun Xu: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Takuya Miyakawa: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Shohei Nosaki: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Akira Nakamura: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Ying Lyu: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Hidemitsu Nakamura: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Umeharu Ohto: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Hanako Ishida: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Toshiyuki Shimizu: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Tadao Asami: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Masaru Tanokura: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-018-06452-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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HTL and D14 receptors perceive the structurally similar signaling compounds karrikin and strigolactone. Here, the authors show that ShD14 and a divergent clade of ShHTLs from Strigae capable of recognizing strigolact are capable of recognizing strigolactone and provide structural insights into the evolution of ligand specificity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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