Frontiers in Nutrition (Oct 2021)

MRI-Derived Subcutaneous and Visceral Adipose Tissue Reference Values for Children Aged 6 to Under 18 Years

  • Kacper Marunowski,
  • Dominik Świętoń,
  • Włodzimierz Bzyl,
  • Małgorzata Grzywińska,
  • Mariusz Kaszubowski,
  • Piotr Bandosz,
  • Piotr Bandosz,
  • Dmitry Khrichenko,
  • Maciej Piskunowicz

DOI
https://doi.org/10.3389/fnut.2021.757274
Journal volume & issue
Vol. 8

Abstract

Read online

The assessment of body composition in pediatric population is essential for proper nutritional support during hospitalization. However, currently available methods have limitations. This study aims to propose a novel approach for nutrition status assessment and introduce magnetic resonance imaging (MRI)-derived subcutaneous and visceral fat normative reference values. A total of 262 healthy subjects aged from 6 to 18 years underwent MRI examinations and anthropometric measurements. MRI images at the second lumbar vertebrae were used by two radiologists to perform the semi-automatic tissue segmentation. Based on obtained adipose tissue surface areas and body mass index (BMI) scores sex-specific standard percentile curves (3rd, 10th, 25th, 50th, 75th, 90th, 97th) and z-scores were constructed using LMS method. Additionally, 85th and 95th centiles of subcutaneous and visceral adipose tissue were proposed as equivalents of overweight and obesity. Bland-Altman plots revealed an excellent intra-observer reproducibility and inter-observer agreement. In conclusion, our findings demonstrate highly reproducible method and suggest that MRI-derived reference values can be implemented in clinical practice.

Keywords