GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection

Tomoko Sumitomo; Masanobu Nakata; Satoshi Nagase; Yuki Takahara; Mariko Honda-Ogawa; Yasushi Mori; Yukako Akamatsu; Masaya Yamaguchi; Shigefumi Okamoto; Shigetada Kawabata

doi:10.1128/mBio.03269-20

mBio (Jun 2021)

GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection

Tomoko Sumitomo,
Masanobu Nakata,
Satoshi Nagase,
Yuki Takahara,
Mariko Honda-Ogawa,
Yasushi Mori,
Yukako Akamatsu,
Masaya Yamaguchi,
Shigefumi Okamoto,
Shigetada Kawabata

Affiliations

Tomoko Sumitomo: ORCiD; Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
Masanobu Nakata: ORCiD; Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
Satoshi Nagase: Department of Clinical Laboratory Science, Faculty of Health Sciences, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
Yuki Takahara: Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
Mariko Honda-Ogawa: Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
Yasushi Mori: Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
Yukako Akamatsu: Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
Masaya Yamaguchi: ORCiD; Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
Shigefumi Okamoto: ORCiD; Department of Clinical Laboratory Science, Faculty of Health Sciences, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
Shigetada Kawabata: Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan

DOI: https://doi.org/10.1128/mBio.03269-20
Journal volume & issue: Vol. 12, no. 3

Abstract

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Secondary bacterial pneumonia following an influenza A virus (IAV) infection is a major cause of morbidity and mortality. Although it is generally accepted that preceding IAV infection leads to increased susceptibility to secondary bacterial infection, details regarding the pathogenic mechanism during the early stage of superinfection remain elusive.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal