Nature Communications (May 2019)

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

  • Patrick A. Baeuerle,
  • Jian Ding,
  • Ekta Patel,
  • Niko Thorausch,
  • Holly Horton,
  • Jessica Gierut,
  • Irene Scarfo,
  • Rashmi Choudhary,
  • Olga Kiner,
  • Janani Krishnamurthy,
  • Bonnie Le,
  • Anna Morath,
  • G. Christian Baldeviano,
  • Justin Quinn,
  • Patrick Tavares,
  • Qi Wei,
  • Solly Weiler,
  • Marcela V. Maus,
  • Daniel Getts,
  • Wolfgang W. Schamel,
  • Robert Hofmeister

DOI
https://doi.org/10.1038/s41467-019-10097-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex, preserving natural regulatory circuits and achieving improved performance in mouse tumor models.