Nature Communications (Sep 2022)
IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses
- M. Clement,
- J. L. Forbester,
- M. Marsden,
- P. Sabberwal,
- M. S. Sommerville,
- D. Wellington,
- S. Dimonte,
- S. Clare,
- K. Harcourt,
- Z. Yin,
- L. Nobre,
- R. Antrobus,
- B. Jin,
- M. Chen,
- S. Makvandi-Nejad,
- J. A. Lindborg,
- S. M. Strittmatter,
- M. P. Weekes,
- R. J. Stanton,
- T. Dong,
- I. R. Humphreys
Affiliations
- M. Clement
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University
- J. L. Forbester
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University
- M. Marsden
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University
- P. Sabberwal
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University
- M. S. Sommerville
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University
- D. Wellington
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University
- S. Dimonte
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University
- S. Clare
- Wellcome Sanger Institute, Wellcome Genome Campus
- K. Harcourt
- Wellcome Sanger Institute, Wellcome Genome Campus
- Z. Yin
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University
- L. Nobre
- Cambridge Institute for Medical Research, University of Cambridge
- R. Antrobus
- Cambridge Institute for Medical Research, University of Cambridge
- B. Jin
- Fourth Military Medical University
- M. Chen
- Department of Microbial Pathogenesis, Yale University School of Medicine
- S. Makvandi-Nejad
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University
- J. A. Lindborg
- Departments of Neurology and Neuroscience, Yale University School of Medicine
- S. M. Strittmatter
- Departments of Neurology and Neuroscience, Yale University School of Medicine
- M. P. Weekes
- Cambridge Institute for Medical Research, University of Cambridge
- R. J. Stanton
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University
- T. Dong
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Oxford University
- I. R. Humphreys
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University
- DOI
- https://doi.org/10.1038/s41467-022-32587-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The effect of IFITM3 on viral pathogenesis is poorly understood. Here, the authors show that IFITM3 restricts cytomegalovirus pathogenesis by reducing Nogo-B-mediated inflammation in response to viral stimuli.
