Oilseeds and fats, crops and lipids (Mar 2017)

Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC®

  • Bernoud-Hubac Nathalie,
  • Hachem Mayssa,
  • Lo Van Amanda,
  • Picq Madeleine,
  • Lagarde Michel

DOI
https://doi.org/10.1051/ocl/2016053
Journal volume & issue
Vol. 24, no. 2
p. D205

Abstract

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Docosahexaenoic acid (DHA; 22:6 ω-3) is highly enriched in the brain and is required for proper brain development and function. Its deficiency has been shown to be linked with the emergence of neurological diseases. Dietary ω-3 fatty acid supplements including DHA have been suggested to improve neuronal development and enhance cognitive functions. Findings suggested that DHA is better incorporated into the brain when esterified at the sn-2 position of a lysophosphatidylcholine (LysoPC-DHA). AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® is a specific and preferred carrier of DHA to the brain. When AceDoPC® was injected to rats that were subjected to an ischemic stroke, it prevents the extension of brain lesions. Regarding the essential role of DHA for cerebral functions, targeting the brain with specific carriers of DHA might provide novel therapeutic approaches to neurodegenerative diseases.

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