Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

Young-Chae Kim; Sunmi Seok; Yang Zhang; Jian Ma; Bo Kong; Grace Guo; Byron Kemper; Jongsook Kim Kemper

doi:10.1038/s41467-020-19803-9

Nature Communications (Nov 2020)

Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

Young-Chae Kim,
Sunmi Seok,
Yang Zhang,
Jian Ma,
Bo Kong,
Grace Guo,
Byron Kemper,
Jongsook Kim Kemper

Affiliations

Young-Chae Kim: Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
Sunmi Seok: Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
Yang Zhang: Computational Biology Department, School of Computer Science, Carnegie Mellon University
Jian Ma: Computational Biology Department, School of Computer Science, Carnegie Mellon University
Bo Kong: Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University
Grace Guo: Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University
Byron Kemper: Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
Jongsook Kim Kemper: Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/s41467-020-19803-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Hepatic lipogenesis is a tightly regulated process, which is elevated in obesity. Here the authors report that FGF15/19, bile acid-induced gut hormones, repress lipogenic genes in the late fed-state by activating small heterodimer partner (SHP) and promoting SHP-dependent recruitment of DNA methyltransferase DNMT3A to lipogenic genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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