Nature Communications (Mar 2016)
Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like
- Seham Ebrahim,
- Matthew R. Avenarius,
- M’hamed Grati,
- Jocelyn F. Krey,
- Alanna M. Windsor,
- Aurea D. Sousa,
- Angela Ballesteros,
- Runjia Cui,
- Bryan A. Millis,
- Felipe T. Salles,
- Michelle A. Baird,
- Michael W. Davidson,
- Sherri M. Jones,
- Dongseok Choi,
- Lijin Dong,
- Manmeet H. Raval,
- Christopher M. Yengo,
- Peter G. Barr-Gillespie,
- Bechara Kachar
Affiliations
- Seham Ebrahim
- Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- Matthew R. Avenarius
- Oregon Hearing Research Center and Vollum Institute, Oregon Health & Science University
- M’hamed Grati
- Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- Jocelyn F. Krey
- Oregon Hearing Research Center and Vollum Institute, Oregon Health & Science University
- Alanna M. Windsor
- Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- Aurea D. Sousa
- Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- Angela Ballesteros
- Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- Runjia Cui
- Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- Bryan A. Millis
- Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- Felipe T. Salles
- Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- Michelle A. Baird
- National High Magnetic Field Laboratory and Department of Biological Science, Florida State University
- Michael W. Davidson
- National High Magnetic Field Laboratory and Department of Biological Science, Florida State University
- Sherri M. Jones
- Department of Special Education and Communication Disorders, University of Nebraska-Lincoln
- Dongseok Choi
- Department of Public Health and Preventive Medicine, Oregon Health and Science University
- Lijin Dong
- Genetic Engineering Core, National Eye Institute, National Institutes of Health
- Manmeet H. Raval
- Department of Cellular and Molecular Physiology, Penn State University College of Medicine
- Christopher M. Yengo
- Department of Cellular and Molecular Physiology, Penn State University College of Medicine
- Peter G. Barr-Gillespie
- Oregon Hearing Research Center and Vollum Institute, Oregon Health & Science University
- Bechara Kachar
- Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
- DOI
- https://doi.org/10.1038/ncomms10833
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
Stereocilia of the inner ear have graded heights that are thought to be regulated by the myosin-III family members MYO3A and MYO3B. Here the authors identify espin-1 and espin-like (ESPNL) as cargo that differentially influence the functions of both motors to regulate stereocilia length.
