Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization

Marta Imamura; Fernando Ezquerro; Fábio Marcon Alfieri; Lucy Vilas Boas; Tania Regina Tozetto-Mendoza; Janini Chen; Levent Özçakar; Lars Arendt-Nielsen; Linamara Rizzo Battistella

doi:10.1155/2015/329792

International Journal of Inflammation (Jan 2015)

Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization

Marta Imamura,
Fernando Ezquerro,
Fábio Marcon Alfieri,
Lucy Vilas Boas,
Tania Regina Tozetto-Mendoza,
Janini Chen,
Levent Özçakar,
Lars Arendt-Nielsen,
Linamara Rizzo Battistella

Affiliations

Marta Imamura: Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil
Fernando Ezquerro: University of São Paulo School of Medicine, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil
Fábio Marcon Alfieri: Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil
Lucy Vilas Boas: Tropical Hematology Laboratory, Institute of Tropical Medicine of São Paulo and Medical Research Laboratory, LIM 52, University of São Paulo, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil
Tania Regina Tozetto-Mendoza: Tropical Hematology Laboratory, Institute of Tropical Medicine of São Paulo and Medical Research Laboratory, LIM 52, University of São Paulo, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil
Janini Chen: Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Domingo de Soto 100, Vila Mariana, 04116-030 São Paulo, SP, Brazil
Levent Özçakar: Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Hacettepe University Faculty of Medicine, Sıhhiye, 06100 Ankara, Turkey
Lars Arendt-Nielsen: Center for Sensory-Motor Interaction, School of Medicine, Aalborg University, Fredrik Bajers Vej 7, Building D3, 9220 Aalborg E, Denmark
Linamara Rizzo Battistella: Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil

DOI: https://doi.org/10.1155/2015/329792
Journal volume & issue: Vol. 2015

Abstract

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Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients’ functional capacity and pressure pain threshold (PPT) values.

Published in International Journal of Inflammation

ISSN: 2090-8040 (Print); 2042-0099 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://www.hindawi.com/journals/iji/

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