Nature Communications (Jan 2022)

Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants

  • Bret Sanders,
  • Daniel D’Andrea,
  • Mark O. Collins,
  • Elliott Rees,
  • Tom G. J. Steward,
  • Ying Zhu,
  • Gareth Chapman,
  • Sophie E. Legge,
  • Antonio F. Pardiñas,
  • Adrian J. Harwood,
  • William P. Gray,
  • Michael C. O’Donovan,
  • Michael J. Owen,
  • Adam C. Errington,
  • Derek J. Blake,
  • Daniel J. Whitcomb,
  • Andrew J. Pocklington,
  • Eunju Shin

DOI
https://doi.org/10.1038/s41467-021-27601-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 21

Abstract

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Coordinated programs of gene expression drive brain development. Here, the authors use human embryonic stem cells and foetal cortical tissue as well as available GWAS statistics and analysis of genetic variants associated with neuropsychiatric disorders and cognition revealing a convergence on transcriptional programs regulating excitatory cortical neurogenesis.