Nature Communications (May 2018)
CCDC102B confers risk of low vision and blindness in high myopia
- Yoshikatsu Hosoda,
- Munemitsu Yoshikawa,
- Masahiro Miyake,
- Yasuharu Tabara,
- Noriaki Shimada,
- Wanting Zhao,
- Akio Oishi,
- Hideo Nakanishi,
- Masayuki Hata,
- Tadamichi Akagi,
- Sotaro Ooto,
- Natsuko Nagaoka,
- Yuxin Fang,
- Nagahama Study group,
- Kyoko Ohno-Matsui,
- Ching-Yu Cheng,
- Seang Mei Saw,
- Ryo Yamada,
- Fumihiko Matsuda,
- Akitaka Tsujikawa,
- Kenji Yamashiro
Affiliations
- Yoshikatsu Hosoda
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Munemitsu Yoshikawa
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Masahiro Miyake
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Yasuharu Tabara
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Noriaki Shimada
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University
- Wanting Zhao
- Singapore Eye Research Institute, Singapore National Eye Centre
- Akio Oishi
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Hideo Nakanishi
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Masayuki Hata
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Tadamichi Akagi
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Sotaro Ooto
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Natsuko Nagaoka
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University
- Yuxin Fang
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University
- Nagahama Study group
- Kyoko Ohno-Matsui
- Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University
- Ching-Yu Cheng
- Singapore Eye Research Institute, Singapore National Eye Centre
- Seang Mei Saw
- Singapore Eye Research Institute, Singapore National Eye Centre
- Ryo Yamada
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Fumihiko Matsuda
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Akitaka Tsujikawa
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- Kenji Yamashiro
- Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-03649-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 7
Abstract
Myopic maculopathy is a complication of myopia that often progresses to blindness. Here, in a genome-wide association study, Hosoda et al. find that rs11873439 intronic to CCDC102B is associated with myopic maculopathy, but not with myopia, thus representing a risk factor independent of myopia.
