Research in Molecular Medicine (May 2014)
Comparative Analysis of Serum Levels of Aluminum and Lead in Dialysis Patients, Pre and post Dialysis
Abstract
Background: Accumulation or deficiency of trace elements can occur in hemodialysis patients and it increases risk of cardiovascular or other organs disorders. Special ions levels such as sodium and bicarbonate in dialysis fluid are accurately regulated but the remaining elements are not regularly measured. Aluminum and lead belong to the biologic performance free heavy metals .They also has a tendency to accumulate in hemodialysis patients. This study aims to compare serum aluminum and lead levels in hemodialysis patients before and after dialysis during 6 months period. Materials and Methods: This comparative longitudinal research has been a comparative long- itudinal research conducted to 86 hemodialysis patients in Imam Khomeini and Fatima Zahra in Sari. Sampling was done on patients for three times (two times before dialysis with 6 months interval and one time after dialysis in the sixth month). It has been measured by spectrophotometer method. In order to compare the metal mean and standard deviation, ANOVA analysis method and also evaluating intra group difference with paired test has been used. Results: In the 100 hemodialysis patients, the mean age and duration of hemodialysis were 57.0±7.3 years and 15.28±5.73 months, respectively. Aluminum level in patient’s serum was 30.7± 6.2 and 37.5 ± 6.8 mg/dl before and after dialysis, respectively. The post-dialysis aluminum level became statistically significant (p<0.05). There was no significant difference between pre dialysis aluminum concentrations during 6 months interval. We weren’t finding significant difference in lead level between the three samples taken. Conclusion: Trace elements status in chronic kidney diseases patients is influenced by a renal function residual, size and dialyzer membrane surface. The water nature also is used for dialysis fluid preparation and composition. Trace elements in ESRD patients differed from healthy individuals. So this issue requires accurate studies on trace elements clinical aspects in ESRD patients.
