Nature Communications (Aug 2018)
Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes
- Imogen Moran,
- Akira Nguyen,
- Weng Hua Khoo,
- Danyal Butt,
- Katherine Bourne,
- Clara Young,
- Jana R. Hermes,
- Maté Biro,
- Gary Gracie,
- Cindy S. Ma,
- C. Mee Ling Munier,
- Fabio Luciani,
- John Zaunders,
- Andrew Parker,
- Anthony D. Kelleher,
- Stuart G. Tangye,
- Peter I. Croucher,
- Robert Brink,
- Mark N. Read,
- Tri Giang Phan
Affiliations
- Imogen Moran
- Immunology Division, Garvan Institute of Medical Research
- Akira Nguyen
- Immunology Division, Garvan Institute of Medical Research
- Weng Hua Khoo
- Division of Bone Biology, Garvan Institute of Medical Research
- Danyal Butt
- Immunology Division, Garvan Institute of Medical Research
- Katherine Bourne
- Immunology Division, Garvan Institute of Medical Research
- Clara Young
- Immunology Division, Garvan Institute of Medical Research
- Jana R. Hermes
- Immunology Division, Garvan Institute of Medical Research
- Maté Biro
- EMBL Australia, Single Molecule Science Node, School of Medical Sciences, UNSW
- Gary Gracie
- Department of Anatomical Pathology, St Vincent’s Hospital
- Cindy S. Ma
- Immunology Division, Garvan Institute of Medical Research
- C. Mee Ling Munier
- The Kirby Institute for Infection and Immunity in Society, UNSW
- Fabio Luciani
- The Kirby Institute for Infection and Immunity in Society, UNSW
- John Zaunders
- The Kirby Institute for Infection and Immunity in Society, UNSW
- Andrew Parker
- Department of Anatomical Pathology, St Vincent’s Hospital
- Anthony D. Kelleher
- The Kirby Institute for Infection and Immunity in Society, UNSW
- Stuart G. Tangye
- Immunology Division, Garvan Institute of Medical Research
- Peter I. Croucher
- St Vincent’s Clinical School, Faculty of Medicine, UNSW
- Robert Brink
- Immunology Division, Garvan Institute of Medical Research
- Mark N. Read
- School of Life and Environmental Sciences and the Charles Perkins Centre, University of Sydney
- Tri Giang Phan
- Immunology Division, Garvan Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-018-05772-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties from the germinal centre, for rapid expansion and the induction of B memory responses.
