A rare case of sphenoid giant cell tumor: Case report &amp; review of imaging features post short-term denosumab treatment

Farid Aassouani, MD; Nizar El Bouardi, PhD; Yahya Charifi, MD; Kaoutar Maadin, MD; Amina Bouziane, MD; Meryem Haloua, PhD; Moulay Youssef Alaoui Lamrani, PhD; Samia Arifi, PhD; Touria Bouhafa, PhD; Meriem Boubbou, PhD; Mustapha Maaroufi, PhD; Badreeddine Alami, PhD

Radiology Case Reports (Oct 2022)

A rare case of sphenoid giant cell tumor: Case report & review of imaging features post short-term denosumab treatment

Farid Aassouani, MD,
Nizar El Bouardi, PhD,
Yahya Charifi, MD,
Kaoutar Maadin, MD,
Amina Bouziane, MD,
Meryem Haloua, PhD,
Moulay Youssef Alaoui Lamrani, PhD,
Samia Arifi, PhD,
Touria Bouhafa, PhD,
Meriem Boubbou, PhD,
Mustapha Maaroufi, PhD,
Badreeddine Alami, PhD

Affiliations

Farid Aassouani, MD: Department of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco; Corresponding author.
Nizar El Bouardi, PhD: Department of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco
Yahya Charifi, MD: Department of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco
Kaoutar Maadin, MD: Department of Medical Oncology, Oncology Hospital, Morocco
Amina Bouziane, MD: Department of Radiotherapy, Oncology Hospital, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco
Meryem Haloua, PhD: Department of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco
Moulay Youssef Alaoui Lamrani, PhD: Department of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco
Samia Arifi, PhD: Department of Medical Oncology, Oncology Hospital, Morocco
Touria Bouhafa, PhD: Department of Radiotherapy, Oncology Hospital, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco
Meriem Boubbou, PhD: Department of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco
Mustapha Maaroufi, PhD: Department of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco
Badreeddine Alami, PhD: Department of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Morocco

Journal volume & issue: Vol. 17, no. 10
pp. 3830 – 3834

Abstract

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Background: Giant cell tumors (GCTs) are locally aggressive but rarely malignant bone neoplasms that uncommonly involve the skull. In this report, we describe a tumor of the sphenoid sinus. Case presentation: A 51-year-old female was presented with headache, and bilateral decreased visual acuity, CT scan, and brain MRI revealed an infra-sellar enhancing tumor expanding to the sellar and supra-sellar region which proved to be a GCT. the patient had received 03 months of preoperative denosumab-based treatment and imaging follow-up showed regression in size and morphology modifications of tumor tissue. Conclusion: This is one of few reports to describe the appearance of sphenoid bone GCT, and the first report to highlight the effects of short-term denosumab treatment in GCTb in such a location.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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